Eastern Caribbean Health Outcomes Network (ECHORN) cohort study
ECHORN is a cross-island collaborative that has developed a population-based, observational cohort study that estimates prevalence of known and potential risk factors for cancer, diabetes, and cardiovascular disease over time. by
Dr. Peter Adams
Yale Transdisciplinary Collaborative Center for Health Disparities Research focused on Precision Medicine (Yale-TCC) by Dr. Peter Adams
The Yale-TCC and is funding wave 2 of the ECHORN cohort study and the following subprojects -
• Subproject 1 - Biobanking: Involves the collection of biological samples to test future hypotheses examining biomarkers and genetic polymorphisms that were collected prior to disease occurrence.
• Subproject 2- Diabetes: A precision medicine approach to identify novel biomarkers associated with type 2 diabetes development, thereby facilitating early diagnosis and potential therapeutic targeting of the disease. The primary objective is to identify biomarkers using state-of-the art metabolomics and genomic analyses of blood and urine collected from participants in the ECHORN cohort study. The central hypothesis is that a unique signature of blood and urine metabolites will predict the development of T2D earlier and more accurately than traditional biomarkers.
• Subproject 3 – Hypertension: The overarching goal of this sub-project is to examine momentary Ambulatory Blood Pressure (ABP) in relation to individual variability in environment, lifestyle, and related contextual factors members of the ECHORN Cohort. Our primary objective is to develop individual level phenotypes of hypertension risk, based on contextual factors and the momentary effects these have on ABP, using advanced analytic techniques. Our central hypothesis is that the integration of individual-specific contextual data with ABP profiles will better classify risk for hypertension.
Paediatric ECHORN Cohort study
The overall objective is to characterize intergenerational factors that contribute to paediatric cardiovascular risk.by
Dr. Peter Adams
Preventing Diabetes Using Lifestyle Intervention and Metformin Escalation –(LIME) Project of the Implementation Core of the Yale-TCC.
The main aim is to determine if evidence-based lifestyle interventions and metformin can be effective to prevent diabetes in Caribbean populations.by
Dr. Peter Adams
Treatment of children with Acute Lymphoblastic Leukemia Clinical trial funded by American Society of Hematologists (ASH). by
Dr. Cherly Alexis (Start January 2018)
Cardiovascular Risk Profiling The Renin Angiostenin Aldosterone System in Low Renin Afro-Caribbean Subjetcs by Dr. Damian Cohall
Ethnopharmacology Barbadian Medicinal Plants: Development of College Land, St. John into a Health and Wellness Tourism Destination by Dr. Damian Cohall
Database of Medicinal Plants of the Caribbean and Possible Interactions with Conventional Medication by Dr. Damian Cohall
Pharmacoepidemiology
Audit of Analgesic Medication Use in the In-patient and Out-patient setting of the Queen Elizabeth Hospital by Dr. Damian Cohall